Hi ace01, and Welcome to SpywareHammer

I have never used Clean Up! myself, preferring CCleaner to do my housework. Try the following - we can remove both cleaners afterwards to regain some space.
Temporary files can quickly build up on your computer causing problems such as slow running, errors when accessing the internet and failure to display online images and video. They can also pose a security risk as they may allow automatic logon to secure sites and they also hold details of your surfing history.
Removing these files manually is possible but an easier way is to use CCleaner.
- Download CCleaner from http://www.piriform.com/ccleaner/builds (Go for the Slim build.)
- Run the downloaded file to install CCleaner.
- Run CCleaner and click 'Search for Updates' (the link is at the bottom right of the window). Update the program if there is a newer version available.
- Go to 'Options' and click the 'Settings' tab, then click 'Advanced'. Uncheck the box against 'Only Delete Files in Windows Temp Folders Older than 48 Hours' and click OK.
- Make sure there are no browser windows open.
- Click 'Run Cleaner'.
- Close the CCleaner window when finished.
- Please note that running CCleaner will force you to enter login and password details for any sites which require them. Make sure you know them!.
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Next, set your browser cache to only store files for 5 days. If you are not sure how to do this, let me know which browser you use (IE8, Firefox or whatever) and I will run through it with you.
If your system is running OK you can regain some space by removing old Restore Points and creating a fresh one. Again, if you are not sure how to do this, let me know what operating system you are running and we can take it from there.
The EULA files should be delete-able but there is a slim chance an application may look for the file to check it is legitimate. I suggest you right click these files and insert a 'zz' at the beginning - eula.txt would become zzeula.txt. If everything still works OK we can delete these later. The other files you mentioned are the uninstall files to roll back Windows updates should they cause problems. If your system is running fine then they can be removed.
Let me know how that goes and we can look into further space saving procedures.